![]() ![]() ![]() ![]() How does an injured organ replace cells that have died as a result of the damage? Making new cells might seem like the best option, because this would restore the organ to how it looked before the injury. developmental states and reveal a tissue-protective role of endocycles. Our data reveal distinct cell cycle programming in response to similar stimuli in mature vs. However, in response to sustained growth signaling, only endocycles preserve epithelial architecture. After injury, both cycles accurately restore tissue mass and genome content. By developing a novel genetic method, DEMISE (Dual-Expression-Method-for-Induced-Site-specific-Eradication), we show the cell cycle regulator Fizzy-related dictates the decision between mitosis and endocycles. Using an acute injury model, we identify mitosis as the response in larval pyloric cells, whereas endocycles occur in adult pyloric cells. Here, we uncover a programmed switch between cell cycles in the Drosophila hindgut pylorus. In these organs, the regulation and distinct roles of different cell cycles remains unclear. Such cycles, including endocycles, are increasingly appreciated to drive tissue growth following injury or activated growth signaling in mature organs. Ploidy-increasing cell cycles drive tissue growth in many developing organs. ![]()
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